This study explores the impact of γ′ precipitate size on the mechanical properties of Ni-based single crystal superalloys. Through experiments and simulations, it’s found that smaller γ′ precipitates result in higher hardness, while a higher volume fraction of γ′ precipitates leads to increased hardness. Additionally, refining γ′ precipitates enhances creep resistance by delaying plastic activity in the material. These findings align with experimental observations and highlight the effectiveness of simulation methods in understanding underlying mechanisms.